Sentence examples for compounds capable of inhibiting from inspiring English sources

Compounds capable of inhibiting deacetylase activity are a powerful tool for dissecting the role of protein acetylation in gene function.

Using bioinformatic tools, we have carefully mapped out a highly conserved and unique region constituted by I85, S149, and A151 in the plasmodial proteases that can influence the development of compounds capable of inhibiting the entire FP family.

Compounds capable of inhibiting Cyp19 (Aromatase), a key enzyme in the synthesis of estrogens, have been successfully employed as breast cancer therapies, while inhibitors of Cyp17 (17α-hydroxylase-17,20-lyase), a key enzyme in the synthesis of glucocorticoids, mineralocorticoids and steroidal sex hormones, are a key component of prostate cancer therapy.

This work describes the completion of an antiviral testing platform (subgenomic system) for KFDV that could be used to quickly and safely screen compounds capable of inhibiting KFDV replication without the requirement for high containment, as the structural genes have been replaced with a luciferase reporter gene precluding the generation of infectious particles.

Antioxidants, i.e., the compounds capable of inhibiting or preventing the substrate oxidation [2, 3], are widely used in medicine, cosmetology, and food industry.

The split-GFP methodology is well suited for a noninvasive high throughput screen to identify compounds capable of inhibiting polyglutamine oligomerization in cells.

In this study, we identify the structural requirements of Gli1/DNA functional interaction and exploit this information to discover a low-molecular-weight compound capable of inhibiting Hh pathway by targeting Gli1.

Because of its potential role in sustaining prostate cancer cell growth after androgen deprivation therapy (ADT), we set out to determine whether a compound capable of inhibiting AED-stimulated LNCaP cell proliferation could be identified from a proprietary steroid library that was developed around the structure of AED.

The first screen of the enzyme using the soluble compounds identified several compounds capable of fully inhibiting the ATPase activity at 100 µM concentration (Fig. 4).

According to in vitro activity assays, a number of these compounds were capable of inhibiting human mPGES-1, with the desirable selectivity for mPGES-1 over COX isozymes.

At a concentration of 300 nM, these inhibitors showed 0.7 15.7% cell protection against ricin (Table 2), confirming that these compounds are capable of inhibiting RTA in the absence of firefly luciferase.