To obtain an optimized T-type calcium channel blocker with reduced off-target hERG toxicity, we modified the structure of the original compound by introducing a zwitterion and reducing the basicity of the nitrogen.
A novel class of hybrid compounds, obtained by introducing a substituted trans-vinylbenzene moiety on a coumarin backbone, was synthesized and evaluated for the antitumor profile.
To seek effective thermally activated delayed fluorescence (TADF) molecules, we have designed compounds 1-4 by introducing substituents on the para-position of boron atom of blue TADF molecule (DABNA-1).
In line with our continueous efforts to synthesize bioactive lead compounds, the title compounds were designed by introducing amide pharmacophore into the valine scaffold.
Ten novel azaoxaisowurtzitane cage compounds were designed by introducing the oxygen atoms into the azaisowurtzitane cage to replace the N-NO2 groups.
But he compounded the handicap by introducing himself to the Republican electorate with a series of symbolic jabs at the party's base.
Then they compound that mess by introducing Phone 8, which is (again) 100% incompatible with Phone 7 (phone 7 apps won't run on it, and vice-versa).
The compounds II were synthesized by introducing of two methylene into the structure I. Compared with the commercial herbicidal clacyfos, compounds II showed moderate herbicidal activity with 60 85% inhibition effect against chingma abutilon (Abutilon theophrasti), common amaranth (Amaranthus retroflexus) and white eclipta (Eclipta prostrate) at a rate of 150 g ai/ha.
The compounds III were designed by introducing open-chain phosphonates, which displayed notable herbicidal activity.
The energy levels of the four compounds were finely tuned by introducing the electron-donating and -withdrawing groups to the triphenylamine core which are supported by the fluorescence spectra and transit fluorescence spectra of the compounds (–H > –CH3 > –Cl > Pyridine > –NO2).
