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Exact(29)
At high doses, SINE compounds block nuclear egress of an XPO1 cargo reporter, but not at lower concentrations that were associated with neuroprotection.
Two of the compounds block the growth of malaria in culture with potencies in the sub-micromolar range.
Furthermore, the results of capillary electrophoresis (CE) suggest that it is through targeting TAR RNA that this series of compounds block the Tat TAR interaction.
Additional work by He's team suggests that the compounds block two kinds of molecular signals: inhibitory molecules embedded in the myelin insulation on axons and inhibitory signals spewed out by support cells that form a scar around the site of injury.
However, results from our experiments indicate that these compounds block TRPM7 channel activity independent of their actions on 5-LO X 5-LO X
Trapped upon phosphorylation by the plasmodial PdxK, these compounds block PLP-dependent enzymes and thus impair the growth of P. falciparum.
Similar(31)
Several compounds blocked human and rat A1 and A2AARs at similar concentrations representing dual A1/A2A antagonists with high selectivity versus the other AR subtypes.
Although all compounds blocked QS, the thiazolidinediones were the most active AI-2 QS inhibitors, with EC50 values in the low micromolar range.
Cellular studies in non-small cell lung cancer (NSCLC) cell lines that include A549, H460 and H1299 showed that compounds blocked invasion, migration and adhesion.
Compounds blocking the formation or action of leukotrienes are potentially beneficial in treatment of several acute and chronic inflammatory diseases of the cardiovascular and respiratory systems.
We recently showed that the surface modification of mordenite with organo-disilane compounds blocked the permeation of molecular nitrogen into the micropores.
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CEO of Professional Science Editing for Scientists @ prosciediting.com