Sentence examples for compounds binding to from inspiring English sources
The method exploits affinity data for a series of organic chemical compounds binding to wild-type and artificially mutated receptors.
The ability to collect kinetic data on compounds binding to therapeutic targets yields new information for lead optimization.
To dissect the physio-pathological pathways in which QR2, MT3 and melatonin meet, one needs more compounds binding to MT3 and/or inhibitors of QR2 enzymatic activity.
Therefore, molecular docking simulations were performed to calculate the receptor-ligand interactions of our synthesized compounds binding to the CB2 receptor.
This makes computing relative affinities of chemically similar compounds binding to a membrane protein possible in order to guide decision making in drug design.
Data mining using resources like Metrabase can be employed to understand, for example, transporter function or the promiscuous nature of compounds binding to transporters competitively or non-competitively.
14 16 The microfluidics system of the biosensor allows the injection of the compound over an immobilised protein and the optical detector measures the direct binding between the two entities based on the difference in refractive index near the surface that occurs as the compound binds, thus allowing a real-time and label-free measurement of compound binding to the target.
Additionally, quantification of compound binding to AR has been limited by an inability to generate sufficient purified recombinant full-length protein9,48.
Despite this, few options are available to directly measure a compound binding to a protein within the more complex cellular and in vivo systems to which they will ultimately be applied1.
More importantly, solution NMR analysis of compound binding to eParE provides better understanding of the molecular interactions between the inhibitor and eParE.
From the structure and dynamics of the protein ligand complex and efficient, detailed free energy calculations an atomic view of the ligand protein interactions is obtained which is used to design a new compound binding to the receptor.
