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Cells were either co-transfected with additional plasmids or treated with compounds as indicated elsewhere and luciferase assays were performed as previously described (Damgaard et al, 2012).
(D) Insulin secretion in isolated primary islets from a human donor in the presence of 16.7 mM glucose and different compounds as indicated.
(C) Insulin secretion in isolated primary islets from ICR mice in the presence of glucose (2 mM or 16.7 mM) and different compounds as indicated.
At E>1.2 V, the global electro-oxidation of both TMTU and TMFDS2+ species yields carbon dioxide, sulphate ions and carbonyl-containing compounds, as indicated by IR spectra.
Progressive radiolytic alteration of biogenic complex hydrocarbon mixtures induces a decrease in the average size and extent of alkylation of polyaromatic hydrocarbons (PAH) and an increase in the abundance of oxygen-containing compounds, as indicated by Py GC MS, and an enrichment in 13C.
6 h after operation, drug cocktail containing diverse chemical compounds as indicated was injected intraperitoneally (i.p).
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Hereby, e is the molar or mass fraction of a chemical compound within another compound as indicated.
For the remaining infection period, the medium was replaced with DMEM/FCS containing 10 μg mL 1 gentamicin and compound as indicated.
Dose response experiments were then performed in triplicate using a serial dilution of the relevant pyrazolone compounds or positive controls as indicated.
Another set of three compounds (A8, A16, and A17), showed no statistically significant decrease in parent peak, but fortunately, there was only one major degradation product for each compound as indicated by the HPLC chromatograms.
FVB mice were treated orally with a single dose (n = 7/dose) of compound as indicated in the associated Figures.
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