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Similar to the native cholesteryl esters, these compounds are extremely hydrophobic and, before any further biological studies, suitable liposomal formulations for these new compounds are required.
For this, large-area samples (≥40 cm2) of 235,238U and 239,242Pu compounds are required for the calibration of fission chambers and for fission yield measurements.
Furthermore, preparative TLC analysis is a costly and tedious process, particularly when compounds are required in significant quantities [25].
With drug discovery now being driven primarily by bio-chemistry and high-throughput screening, the biological effects and, in particular, the pharmacology and toxicity of new compounds are required to be studied and evaluated properly before they are released.
As of 2002, > 650 toxic chemicals and chemical compounds are required to be reported.
This undesired effect of doxorubicin suggested that, more p53-selective compounds are required for cyclotherapy to be a successful approach.
Similar(45)
Synthesis of fewer than a dozen compounds was required to achieve inhibition of the growth of methicillin-resistant Staphyloccus aureus (MRSA) at compound concentrations of 1.56 μM.
However, a better understanding of their PO4 removal mechanisms, and reactions that could lead to the formation of PO4 compounds, is required to evaluate the potential utility of candidate sorbents.
With the emergence of combinatorial chemistry in drug discovery the measurement of physico-chemical parameters for a large number of compounds is required at a much earlier stage of the drug discovery process.
A deeper cleaning of sulfur compounds is required for the DFC application.
We do not know which compounds were required for the origin of life.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com