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Although the thermochemical and thermophysical properties of minor actinide compounds are essential for the design of MA-bearing fuels and analysis of their behavior, the experimental data on minor actinide compounds are limited.
Such compounds are essential for the development of diamidine derivative pairing rules for a novel DNA minor groove binding language.
As shown in Tables 1 and 2, evaluation studies in in vivo systems and further clinical testing of lead compounds are essential for establishing the effectiveness of the potential compounds.
It is obvious that further understanding the molecular mechanism of cccDNA biosynthesis, maintenance and functional regulation as well as developing convenient cell-based assays for investigation of cccDNA biology and search of cccDNA-targeting compounds are essential for development of antiviral drugs to eliminate or silence cccDNA.
In addition to achieving these synergistic effects, the combinations of two or more compounds are essential for the following reasons: (1) to prevent or suppress the emergence of resistant strains, (2) to decrease dose-related toxicity, as a result dosage, and (3) to attain a broad spectrum of activity [ 28].
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The diversity of natural compounds is essential for their mechanism of action.
The knowledge of accurate hydrogen solubility values in bio-oil compounds is essential for the design and optimization of hydroprocesses relevant to biofuel industry.
The shikimate pathway, responsible for the biosynthesis of aromatic compounds, is essential for the growth of Mycobacterium tuberculosis and is a potential target for the design of new anti-tuberculosis drugs.
Although we do not presently know which compounds were essential for the origin of life, it seems possible to preclude certain environments if even fairly simple organic compounds were involved (Cleaves and Chalmers 2004).
Therefore, the early evaluation of the bioactivity profiles of lead compounds is essential for the success in developing new drugs, although efficacy is sometimes attained by the inhibition of single targets, e.g. viral proteins.
Extensive characterization of the composition of the bactericidal compounds is essential for application of medical-grade honey as a topical antimicrobial agent in modern medicine.
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