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Several steroidal STS inhibitors have been reported, but steroidal compounds are difficult to optimize and may interact with other targets.
Due to their low concentration, fast turnover, and limited spatial distribution throughout the soil, root-derived compounds are difficult to study.
Factors such as relevant physiologic concentrations and metabolism of putative chemoprevention compounds are difficult to model in an in vitro system.
Dyes, pigments, and their causative compounds are difficult for industrialization since they are highly carcinogenic and undesirable in water as reported.
Complex phenotypes, such as strain tolerance to toxic compounds, are difficult to be rationally engineered due to the limited knowledge about molecular mechanism.
Measurements on the evaporation of the least volatile aerosol compounds are difficult since only minimal changes in the monitored parameter, e.g. CIMS signal, as a function of temperature are observed, and Δ Hvap close to zero is obtained.
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Biological oxidation of chlorophenol compounds is difficult because of toxic effects of those compounds on microorganisms.
Remediation of these synthetic compounds is difficult and an enormous logistical task.
Evaluation of the oxygen reduction reaction (ORR) on oxide compounds is difficult owing to the insulating nature of oxides.
The two compounds were difficult to separate.
Moreover, in most cases these do not allow a comparison between the compound's features and a complete and correct set of compounds is difficult to be returned.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com