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Using pharmacological and caged compounds approaches to modify [Ca2+]i during learning, we demonstrate that Ca2+ is both necessary and sufficient during acquisition for LTM formation.
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Methodical modification of culture growing conditions is often referred to as the OSMAC (one strain, many compounds) approach (Bode et al., 2002; Scherlach & Hertweck, 2006).
The deliberate elaboration of cultivation parameters to influence the secondary metabolism of a strain has been called the OSMAC (one strain, many compounds) approach (Bode et al. 2002).
All third-generation compounds approach nearly complete suppression of total-body aromatization and plasma estrogen levels [ 40, 41].
The OSMAC (one strain, many compounds) approach has been proposed as an alternative way of exploring each strain in multiple conditions to better exploit their specialized metabolism and to trigger part of this microbial biosynthetic potential [ 43].
This might be one key to induce the expression of acarbose and novel secondary metabolite gene clusters by appropriately composed cultivation media following the OSMAC (one strain, many compounds) approach [ 53].
Cancer risk estimates corresponding to the 95th percentile biomarker concentrations for 12 of the 13 compounds with available cancer-based screening values exceed the 10 6 cancer risk level, and cancer risk estimates corresponding to the GM biomarker concentrations for 8 of these compounds approach or exceed the 10 4 cancer risk level (see Figure 3).
A simple plan was devised to combine a larger alkali metal (potassium) with a smaller fitting cap (TMEDA instead of tridentate PMDETA) in the hope of encouraging closer intramolecular contact between incipient anion bridges as two distinct metal compounds approach each other to generate a bimetallic assembly.
For the compound approaches, CA is done first and only once.
The effort of the compound approaches that do the CA first (Hungarian CA or improved Greedy CA) and a PA afterwards can be interpreted as combination of CA and PA efforts.
"It was a compound approach to that all-amenities building".
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