It identifies features shared by different subsets of active compounds and accordingly filters out compounds within the target data set in which these combinations are lacking.
As the oxygen atoms were bonded to the sulfur atoms, dipole moment of the sulfur compounds increased accordingly, and thus their dissolving capacity in the polar solvents (DMF, DMSO, etc.,) was enhanced significantly.
Hence, the compound with the highest/median/minimum feature value is painted solid, and the remaining compounds are sorted accordingly.
Accordingly, compounds with low feature values are colored blue, while compounds with high feature values are colored red (see Figures 13 and 11).
Accordingly, compounds with a value close to 0 have low embedding stress, whereas a value close to 1 corresponds to high stress.
Accordingly, compounds possessing, besides anticholinergic activity and β-amyloid aggregation inhibition properties, metal chelating and/or nitric oxide releasing properties with additional antioxidant capacity were developed.
Accordingly, compounds 5 9, 11, 15 18, 21, 22, 24, 25, 27 and 28 were active against CVB4, and compounds 5 and 24 were active against HSV-1 and 2 in comparison to ribavirin and acyclovir, which were used as reference drugs.
