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This may be due to a combination of compounded exposure to TB risk factors, poor healthcare access and, possibly, genetic factors [ 60].
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Computational toxicology aims at predicting in silico the health and environmental risks associated to compound exposure or intake.
Moreover, many of these women live on or near farms, which may compound exposures to farm chemicals and other risk factors.
That may be compounded by exposure of new human populations, with perhaps different genetic vulnerabilities; transmission at a new scale; or other factors yet to be determined.
Classically, morphological assessment of the embryos is applied to evaluate the effects of compound exposure.
There was no direct correlation between compound exposure and in vivo activity.
After compound exposure, cell viability was assessed by the commonly used MTT assay.
Compounds with a CIx ≥ 0.80 (i.e. 20% or less difference in cell viability between compound and BA co-exposure and compound exposure alone) were considered to have a low cholestatic risk, whereas compounds with a CIx ≤ 0.80 were considered to have cholestatic risk.
This study was designed to determine cytotoxic effects of PBDE-47 and HBCDs individually or with a mixture of both compounds exposure to Hep G2 cells.
Hepatic ethoxyresorufin-O-deethylase activity, a biomarker of dioxin-like compound exposure, was induced by 12-fold in the 4600 pg/g treatment relative to controls.
With the live cell imaging systems, cellular activity like mode of death, proliferation and inhibition as a result nanoparticle or other compounds exposure can be studied.
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