Three compounds in the second screen were categorized as resistance due to selection (Table S1) and one compound was categorized as resistance due to the mismatch repair defective phenotype (Table S2).
Initial analyses examined the effect of mutual adjustment for the three DDT-related compounds— p,p′ -DDT, o,p′ -DDT, and p,p′ -DDE where each compound was categorized in tertiles based on the control population and represented as two nominal variables: tertile 2 and tertile 3, where tertile 1 was the reference category.
These ZM compounds were categorized according to the nature of the cyclic amino groups into ZM2, ZM3, ZM4, and ZM5 and were shown to reduce carrageenan-induced inflammation, inhibit cyclooxygenase (1 and 2) and have less adverse effects than the common non-steroidal anti-inflammatory drugs.
Six compounds were categorized as resistance due to the mismatch repair defective phenotype (Table S2).
In the initial NIH screen, two compounds (Celastrol and NSC 1011) causing particularly prolonged lag phases were found (Table S1) and two compounds were categorized as resistance due to the mismatch repair defective phenotype (Table S2).
Chemical compounds are categorized as molecular compounds, salts, intermetallic compounds or complex compounds.
The compounds are categorized against their functional groups to form seven groups: esters, carboxylic acids, aldehydes and ketones, phenols, alcohols, ethers and alkanes.
These compounds are categorized into primary and secondary metabolites, where the former are involved in housekeeping functions and the latter are used by plants in interactions with their environment [1].
A total of 13 compounds from this screen were categorized as resistance due to selection (Table S1).
A total of 323 SSRs were categorized as compound repeats.
