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Afterwards, the nitrogen source compound was optimized to reduce both, ammonium and nitrate concentrations.
The new lead compound was optimized for potency, selectivity, and for its ADME properties.
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In later stages of drug discovery, a lead compound is optimized for desired biophysical properties.
This compound is optimized for NF-κB inhibition, membrane insertion and glucocorticoid receptor (GR) specificity.
The concentration of bioactive compounds was optimized using Response Surface Methodology, with a 22 central composite rotational design and germination time and temperature as independent variables.
The LC enantioseparation of chiral acidic and zwitterionic drugs selected as model compounds was optimized using chlorine containing cellulose based chiral stationary phases and polar organic mobile phases.
Next, we have elaborated of the HS-SPME-GC-MS/MS method for analysis of CWA degradation products in environmental samples using laboratory obtained fibers The analytical method for analysis of organosulfur and organoarsenic compounds was optimized and validated.
Compounds were optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties.
The influence of process parameters on the removal of carbohydrates, phenolics and antioxidant compounds were optimized using Response Surface Factorial Design and the Taguchi method.
In addition to the experimental work, the ground state geometries of the hybrid compounds were optimized using Density Functional Theory applications at the B3LYP/6-31G d B3LYP/6-31G drder to obtain information about the 3D geometries and electronic structure.
Tsu, unpublished work), compounds were optimized for in vitro β5 potency against human 20S, whereas crystal structures of representative examples were determined with the yeast 20S open-gate mutant in order to guide further library design.
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