Sentence examples for compound was modified from inspiring English sources

For each compound in the entire Vss-target dataset (including both the training (model selection) and external datasets), the value of the predicted adipose tissue's log Kt:p descriptor in that compound was modified by adding or subtracting 10% of the current descriptor value, where the decision to perform addition or subtraction was made at random.

This glycosaminoglycan- (GAG-) like compound was modified in a classical solvent (N,N′-dimethylformamide).

Therefore, the first step of the synthesis protocol, i.e. loading of the CS with a copper compound, was modified and the copper complex [Cu(NH3 4(H2O)2]2+ was employed instead of Cu(NO3 2.

When an effect is detected, the compound is modified in different ways to optimize its activity and specificity.

The natural enantiopure compound is modified to create the desired enantiopure drug.

A sensitivity analysis study is similar to genetic or chemical modification experiments in which specific features of a lead compound are modified to examine whether they affect properties such as binding affinity.

It is necessary to follow up the modification chemistry with a befitting biochemical or cell-based assay to ensure that activity is retained when a compound is modified for immobilization.

Lead compounds were modified to investigate the possible role that zinc binding may play in inhibitor efficacy.

It is especially significant that the three effective compounds are modified at the site of the acceptor atom in the natural substrate.

However, six different analogues of epothilones are in preclinical and clinical trials including patupilone (epothilone A and B), ixabepilone (BMS247550), BMS 310705, sagopilone (ZK-EPO), KOS-862 (epothilone D), and KOS-1584, etc. where all of these compounds were modified from major product of myxo-bacterium (epothilone A and B) (Cheng et al. [2008]).

In phase I toxic compounds are modified resulting in more reactive metabolites.