Suggestions(1)
Exact(3)
We measured serum concentrations of all three compounds; the peak serum level for the parent compound was approximately two hours post dose.
This compound was approximately 16-fold less potent than bisphenol E, exhibiting an IC50 value of 131 nM (Table 1).
Following administration of roflumilast 500mcg to 18 healthy volunteers, the half-life of the parent compound was approximately 14 h (range 9 22.8 h) (Manegold et al. 2002a), thus supporting once-daily dosing.
Similar(57)
The inability of acutely administered Boc5 to elicit insulin responses under hyperinsulinemia may result from its poor potency as the compound is approximately 2700 times less potent than exenatide (Fig. 4B).
In vitro skin penetration (into) for each compound is approximately equal, but skin permeation (through) is greater for tacrolimus ointment than pimecrolimus cream [ 108, 109].
The critical HRT for both compounds was approximately 1 d, which corresponded to a velocity of 21.2 cm d−1.
However, set B (74 compounds) was approximately double the size of set A (33 compounds).
In the NCI database ( http://cactus.nci.nih.gov/ncidb2.2/), the ratio of the number of chemical compounds with k-augmented tree structures to that of all registered chemical compounds is approximately 9%, 22%, 28%, 20%, and 11% for k=0,1,2,3, and 4, respectively.
These three compounds were approximately 30-fold more potent in the bone resorption assay than L-833905 [ 13, 25].
The maximal efficacy and ED50 of AC163794 were comparable with [ d-Ala]GIP(1 42), with both compounds being approximately 100-fold more potent than native GIP.
The SP enantiomers of the nerve agent model compounds were approximately 50-fold more potent with respect to inhibition of hBChE hydrolysis of BTC than their corresponding RP enantiomers.
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