Sentence examples for compound toxicity is from inspiring English sources

The early assessment of compound toxicity is crucial in drug discovery to dismiss drug candidates displaying undesirable safety profiles.

This indicates that either adult or larval feeding experience, possibly combined with inherent compound toxicity, is important in determining future larval performance.

In vitro assays for compound toxicity are commonly based on the assumption that toxicants exposure results in changes in gene expression, a biological phenomenon predictive of successive morphological abnormalities [ 1– 3].

Number of studies concerning monitoring of drugs and their metabolites, analysis of metabolome of volatile as well as non-volatile compounds, determination of ligand-protein binding, permeability and compound toxicity was already reported.

Current efforts that will expand this technology to an influential, high throughput, electrophysiological approach for reliable determinations of compound toxicity are also described and a comprehensive review of toxicological publications using MEAs is provided as an appendix to this publication.

At first the problem of the gadolinium compounds toxicity was reviewed identifying the Motexafin Gadolinium as the best.

Compounds toxicity was determined using cell titer glow (Promega, Madison, WI, USA).

As the development of new antibiotics is lengthy and costly, early monitoring of compound's toxicity is essential in the development of novel agents.

Based on positive results seen through the use of the heterozygous Trp53 mouse in accurately determining compound toxicity, there is the potential for the heterozygous Tp53 knockout rat to be similarly useful.

Compound mediated toxicity was assessed by LDH assay, and was shown to be non-significant at all concentrations tested (data not shown).

Different compounds may also require different host engineering approaches, as the nature of toxicity is compound dependent.