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Curcumin is a nontoxic phenolic compound that modulates the activity of several cellular targets that have been linked with cancers and other chronic diseases.
The effects of SK&F 96365 were independent of cell type and of agonist, as would be expected for a compound that modulates post-receptor events.
Male mice were exposed to both an antiandrogen, vinclozolin, and to a compound that modulates serum androgen levels, indole-3-carbinol, to test the utility of this ratio as a biomarker of androgen disruption.
Interestingly, the supramolecular structure disassembling by organic acid that was well reported, release bioactive compound that modulates root architecture and increase epiphytic and endophytic bacteria colonization.
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Selective estrogen receptor modulators (SERMs) are a category of compounds that modulate the activity and expression of ERs in selected cells such as NSCLC [ 2, 3].
Improved animal models of partial glutamate dysfunction are therefore required to explore the neurochemical basis of psychiatric disorders and to evaluate compounds that modulate glutamatergic neurotransmission.
Thus, this system has the potential to greatly accelerate the discovery of compounds that modulate the fructose transport activity of GLUT5.
Building on these key discoveries, a team of scientists at Vertex, led by Paul Negulescu, initiated research in 1998 to identify compounds that modulate the function of the CFTR protein.
However, wider application of this methodological approach to more differentiated cells such as neurons would also be useful for the screening of compounds that modulate synaptic transmission.
The mammary gland, along with uterine tissue, is a sensitive indicator of the functional activity of the hypothalamic pituitary-gonadal axis so that its histological assessment provides important information about compounds that modulate this activity.
All of the above compounds that modulate the functions of the endocannabinoid system can be collectively described under the term cannabinergics, regardless of chemical classification or type of resultant pharmacological action.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com