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Coincubation with SOD attenuated the amplitude of DEP-induced EPR signals to a similar extent to radical generation by pyrogallol, a compound that generates super-oxide via auto-oxidation in aqueous solution (Marklund and Marklund 1974).
In contrast, a significant neighboring well effect was observed with phenylketophosphamide, a compound that generates phosphoramide mustard but not acrolein.
RESULTS: Didechloro-4-hydroperoxycyclophosphamide, a compound that generates acrolein and a nontoxic analogue of phosphoramide mustard, gave no cross-well toxicity.
Inositol is a versatile compound that generates diversified derivatives upon phosphorylation.
Oxaliplatin is an antineoplastic platinum-based compound that generates DNA adducts which tightly bind HMGB1.
Oxaliplatin is an antineoplastic platinum-based compound that generates DNA adducts that strongly bind HMGB1.
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In response to many foreign compounds that generate oxidative stress, the transcription of certain protective genes is induced via specific DNA motifs called electrophile response elements (EPREs).
These results indicate that modification of the 3-position is essential to make the activities of 6FP available in the dark and would be suggestive for designing pharmaceutical compounds that generate appropriate and controllable amounts of ROS in vivo.
NMs and NPs are perceived as very promising in cancer therapy since they can perform as drug carriers, as well as photo- or sonosensitizers (compounds that generate the formation of reactive oxygen species as a result of either electromagnetic radiation excitation with an adequate wavelength or ultrasound activation, respectively).
The sulA gene is activated as part of the cellular SOS response induced by compounds that generate DNA damage or affect DNA replication [28].
Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response.
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