Sentence examples for compound that binds from inspiring English sources

Schlecht et al. recently demonstrated the inhibition of HSP70 and HSC70 (a constantly expressed isozyme of HSP70) using VER-155008, a compound that binds the nucleotide binding domain of these proteins and reduces their ATPase activity (Table 1).

In both cases, 5-10% DMSO decreased stacking interactions and increased local disorder in noncanonical residues within bulges and loops and resulted in 0.3-4-fold reduction in the measured binding affinities for different small molecules, with the greatest reduction observed for an intercalating compound that binds RNA nonspecifically.

The most rigorous definition of a true endogenous ligand is a compound that binds the LBP in vivo in the absence of experimental probes or other perturbations.

Rhizoxin is a macrocyclic lactone compound that binds to tubulin and inhibits microtubule assembly.

Cisplatin, the most common first line chemotherapeutic drug, is a platinum compound that binds to and cross-links DNA [ 11].

2,3,7,8-Tetrachlorobenzo- p-dioxin (TCDD), a halogenated compound that binds the aryl hydrocarbon receptor, is a by-product of numerous industrial processes including waste incineration.

Finally, Hopkins and co-workers used their method to predict the drug-likeness of 167,045 ligand compounds that bind to 1,729 proteins (on the basis of binding information from ChEMBL, a database of biologically active compounds11).

Then, using the compounds that bind well (levels 4 and 5), a second factor was found defining binding Specificity.

Compounds that bind the protein will give positive peaks whereas peaks generated from non-binding compounds will be negative in the waterLOGSY spectrum.

Similar complex-binding mechanism has been observed and well documented for many natural compounds that bind to protein protein, protein DNA or protein small molecule complexes.

Fragments are typically <250 Da compounds that bind to proteins with weak affinity but high ligand efficiency.