In Chem2Bio2RDF, there are eight kinds of relations: compound-compound, compound-gene, compound-disease, compound-side effect, compound-pathway, gene-gene, gene-disease, and gene-pathway.
The other problem is that because of their chemical similarities, consuming too much caffeine can compound any side effects of theophylline.
Although the wide use of quinacrine demonstrates that it is a generally safe compound, some side effects have been identified.
It may be further compounded by side effects of antipsychotic medication, which include metabolic side effects such as diabetes mellitus and weight gain [ 6, 7].
The development of muraglitazar and tesaglitazar was discontinued due to compound-specific side effects that included elevated risk of cardiovascular events for muraglitazar 20 and decreased renal function for tesaglitazar.
In any case it is recommended to use compounds showing side effects on weight and hunger, and it is better to choose pro-anorectic antidepressants molecules to improve treatment compliance.
If magnesium sulphate is found to be effective in the prevention of post-ERCP pancreatitis, this inexpensive compound with minimal side effects could become a routine pharmacological prophylaxis for post-ERCP pancreatitis.
It is therefore hoped that adding poly ethylene glycol will produce a longer-lasting compound with fewer side effects, although it remains to be established whether pegylation does indeed confer these advantages in clinical practice [ 66].
However, these compounds have many side effects and are not very effective [4].
Based on the knowledge gained about the divergent factors controlling the processes of secretion of electrolytes and motility, many interventional strategies have been adopted by researchers and numerous antidiarrheal compounds have been developed but not many compounds are without side effects and therefore there has always been a need for finding new ones.
