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Efflux pumps related to metal compound resistance are not discussed here.
The analysis of the Y332S hBChE variant suggested yet another mechanism for nerve agent model compound resistance.
In an effort to identify SINE compound resistance mechanisms exploited by HT1080 cells, we used gene expression profiling analysis to compare expression patterns between parental and resistant cells.
One approach for determining the mode of action of a small molecule involves the selection and full genome sequencing of mutants that acquire compound resistance.
Molecular dynamics simulations of these variants revealed insights into the mechanism by which these structural changes conferred nerve agent model compound resistance.
As shown by kinetic data and molecular dynamics studies, these hBChE variants showed a unique mechanism of nerve agent model compound resistance.
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Annotation of such reads revealed that almost 50% of them were related to antibiotic and toxic compounds resistance genes, which are extremely important features for microbial survival and adaptation in polluted environments.
Furthermore, the FRC24 integron contains the antiseptic (quaternary ammonium compounds) resistance gene qacH.
While the majority of cases initially respond to the platinum compounds, resistance eventually develops by mechanisms that remain poorly defined (Shah and Schwartz, 2001).
GyrA sequences carrying TRAs at both the 83 and 87 position are known to confer compounded resistance to quinolones relative to bacteria with a single resistance allele at either position (Conrad et al. 1996; Oh et al. 2001).
Biocide (e.g., alcohol, aldehyde, biguanides (chlorhexidine), quartenary ammonium compounds, zinc, phenolic compounds) resistance has been rarely detected among enterococcal strains, despite its frequent detection in clinical isolates of other Firmicutes, e.g. the emergence of QAC resistance in Methicillin Resistant Staphylococcus aureus due to acquisition of plasmid-borne qac genes [ 132, 133].
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