Sentence examples for compound progression from inspiring English sources

The exploding costs of drug development, and in particular in the neurosciences, make it imperative that decisions about compound progression are made as early as possible, in order to terminate unsuitable candidates before they reach later, more expensive phases of development.

Figure 3 provides a guide for how robust the data were to support the compound progression for each of the therapeutic approaches discussed.

Moreover, enabling technologies, such as real-time visualization and quick simulations prior to all in vivo experiments, could impact assumptions, trigger learning, and optimize use of animal resources, and enable rational integrative decision making on target and compound progression.

Although not considered critical for compound progression, intracellular activity is highly desirable for new chemical hits, as it demonstrates the compound′s ability to kill tuberculosis bacteria growing inside macrophages.

Although this compound progression flow did provide a large number of BCG-selective hits, we were confident that no M. bovis BCG positives from this screen with potential for M. tuberculosis inhibition were left out of the H37Rv MIC determination.

In addition to the global assessment of compound promiscuity, progression of promiscuity was also monitored for individual compounds.

Overall, significant increases in the number of compounds, targets, assays, and activity records were observed, especially from 2007 on, thus providing a sound basis for the analysis of compound promiscuity progression over time.

In this Letter, we extend this concept and incorporate results from a high throughput cytotoxicity assay to help the drug discovery community select compounds for progression into in vivo studies.

Cholestasis is a reduction in bile flow that leads to the intrahepatic accumulation of bile acids and other toxic compounds with progression of liver pathology, including hepatocellular injury and fibrosis [ 1].

A representative compound blocked the progression of nonalcoholic steatohepatitis (NASH) in an animal model.

The result of these screening campaigns has been the identification of thousands of compounds, which have progressed through to accurate IC50 determination against the parasite and measurement of their selectivity index against mammalian cells, resulting in the selection of lead compound series for progression into the next stages of the malaria drug discovery process.