Sentence examples for compound potency from inspiring English sources

Selectivity is assessed based on pair-wise compound potency ratios.

In silico predictive models have proved valuable for the optimisation of compound potency, selectivity and safety profiles.

We tested this strategy on the ferroptosis inducer and experimental therapeutic erastin, and observed substantial increases in compound potency.

In silico predictive models have proved to be valuable for the optimisation of compound potency, selectivity and safety profiles in the drug discovery process.

This allows the definition multiple selectivity queries involving the comparison of an arbitrary number of targets and compound potency values or ratios.

In general, substructures decreasing bioactivity tend to be small and less informative (e.g. single atoms or substructures with two heavy atoms), than those fostering compound potency.

Compound potencies from the TEL-JAK Ba/F3 pSTassayssays were similar to those determined in downstream cell proliferation measurements and more physiologically relevant cytokine-induced pSTAT5 PBMC assays.

Figure 5 shows the concentration−response relationships for these compounds, and compound potencies ranged from ∼33 nM to 1 μM.

We characterized IC50 values for different readouts and showed that counting Live cells or calcein AM-positive cells in spheroids provides the greatest sensitivity to compound effects and best curve fit and can be efficiently used for ranking compound potencies.

Subsequent analogue design and synthesis has been undertaken in order to improve the physicochemical properties (solubility, predicted CNS penetration) and to reduce these compounds' potency against human PI3Ks and mTOR.

For each estrogenic compound, estrogenic potency corresponding to the concentration yielding half-maximum activity (EC50 value) and relative transactivation potency (RTP) were calculated {RTP = [EC50 (E2)/EC50 (test compound)] × 100}.