Sentence examples for compound phenotype from inspiring English sources

Multidrug-resistant (MDR) cell lines often have a compound phenotype, combining reduced drug accumulation with a decrease in topoisomerase II.

In the model proposed by the authors, the UV sensitivity of BRCA1-deficient cells may be a compound phenotype from the perturbed intra-S phase and G2/M checkpoints, lesion removal, and TLS.

Given the wide range of substrates of FURIN, the overall result is probably a compound phenotype caused by complete or partial inhibition of cleavage of a number of substrates.

In the present case, our observations do not support the hypothesis that inheritance of two mutant TP53 alleles may lead to a compound phenotype with increased risk for early onset cancer.

Specifically, when applied to our TRIM24 drug discovery project, the ability to monitor displacement of endogenous full-length TRIM24 from chromatin in adherent cell line enables pivotal PK/PD/efficacy studies to ensure that the compound phenotype (i.e., anti-viability) is not due to off-target effects, but rather linked to on-target TRIM24 activity.

Small amounts of mRNA were used to be able to observe compound phenotypes in co-injected embryos.

This Mecp2 allelic series allows resolution of the compound phenotypes underlying these causes of RTT.

Both R133C and T158M mutations cause compound phenotypes at the molecular level, combining compromised DNA binding with reduced stability, the destabilizing effect of T158M being more severe.

Dramatic decreases in vegetative profilin gene expression produce more compounded phenotypes, suggesting that there is a direct correlation between profilin concentrations and defects in development.

The "chemical compound accumulation" phenotype was very discriminating, with 33/45 descriptions in full agreement with the biology, 3/45 descriptions showing no change between is-mutant and is-WT.

CBP −/−, p300 −/− and CBP +/−; p300 +/− mice all die during embryogenesis, with the compound heterozygous phenotype indicating that the combined amount of the two proteins is limiting [ 34, 35].