Although the mean potency of activity cliff compounds and other active compounds was overall very similar, compound pathways originating from 54% of all activity cliffs successfully reached highly potent compounds, compared to only 28% of pathways originating from compounds not involved in cliff formation.
The results demonstrate that the sulfhydryl compounds pathway is involved in the gastroprotective effect promoted by the fractions studied.> -wrap-foot> ANOVA followed by Dunnett's test.* p < 0.05, ** p < 0.01.
In Chem2Bio2RDF, there are eight kinds of relations: compound-compound, compound-gene, compound-disease, compound-side effect, compound-pathway, gene-gene, gene-disease, and gene-pathway.
The metabolic reconstruction of aromatic compounds pathways in in model environmental bacteria has been achieved by genome sequence analyses [3], [12] [14].
In the 'Metabolic Engineering Target Selection' table, relationships among compounds, pathways, correlated pathways and genes are available.
The database can be browsed for compounds, pathways, reactions, enzymes, their genes and organisms.
MESSI incorporated information of compounds, pathways and genes and their relationships from KEGG database using KEGG API REST.
The tree suggested a recent evolution of the genes belonging to the alkanesulfonates and organosulfur compounds pathways.
In Clusters II and III, including ethylene and many volatile compounds, pathways enriched in positively correlated genes include the TCA and glycolysis pathways.
