While each plot condenses information from at least 9 SPECT images (three animals, three time points) or even from ≈500 (all animals, all time points as in Fig. 3a), the subdivision into tissues and compounds, and the choice of parameters and various plot types resulted again in an expansion, here to >1000 plots.
Each model has 4 parameters, two time constants and two compound gain/threshold parameters of nociceptive fibres and dorsal horn neurons.
As a quantitative instrument it can be used to measure dependence of concentration of compounds on operating parameters of detectors, e.g. gas amplification and irradiation rate and type.
Addition of the compound accumulation parameters to the PCAs likewise did not substantially alter the relative positions of the compounds compared to the PCA carried out using only the 20 chemical parameters.
An orthogonal array design (OAD), OA9 34), was employed for optimization of supercritical fluid extraction of parameters of the compound.
Hence, the GDN CEOS has five inputs per substance: the critical temperature (Tc), the critical pressure (Pc), the critical compressibility factor (Zc) and two compound specific parameters (m, n) of the alpha function.
The clinical studies and case reports have differing dosing approaches, choices of compound, and outcome parameters (Table 4).
Since the model is expressed with functions of the compound parameters θ and τ, the mutation rate is fixed and behaves as a scale parameter.
For MRM, all compounds were optimized for their fragmentation patterns and compound dependent parameters and subsequent separation of compounds was achieved using Purospher® STAR RP-18 (55 mm × 4 mm, 3 μm, Merck, Darmstadt, Germany) column with guard.
For these compounds shielding parameters of 0.2 were used, effectively removing the shielding influence from the Coulomb potential.
Another important set of compound-specific parameters are the Kp values which are used to characterize the distribution or "movement" of the compound into different tissues in the body.
