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It is also worth note that lactate is an intermediate compound of normal metabolism.
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However, a detailed analysis of the effect of these compounds on normal central nervous system function as well as in pathological conditions have yet to be described.
These results indicated the safety of this compound for normal hematopoiesis.
To further confirm the safety of this compound for normal hematopoiesis, we performed colony formation assay using CD34+ human cord blood cells.
Table 3 CC50 values and selectivity index (SI) of the most active compounds on normal VERO Test compound (CC50)a (µg/mL) Selectivity index (SI b 10 250 10 13 125 5 aCC50 is the concentration of compound required to kill 50% of the fibroblast cells bThe selectivity index (SI) was calculated using the formula, SI = CC50/MIC.
Indeed, local application of various compounds to normal joints elicits a frequency and burst profile of joint afferents that is similar to recordings made in arthritic knees.
In contrast, the acute in vivo toxicity test (oral and intravenous administrations) using mice has not shown abnormal signs (data not shown) indicating that the cellular toxicity of the candidate compounds to normal tissue is residual.
A suitable compound for the treatment of normal tension glaucoma should at least act hemodynamically neutral.
Deletion of rifR gene encoding TEII from rifamycin B hybrid PKS/NRPS of Amycolatopsis mediterranei lowered production of this compound to 40 60 % of normal levels (Doi-Katayama et al. 2000).
To evaluate potential bias introduced by formalin fixation, matched FFPE and frozen (Optimal Cutting Temperature compound [OCT]-embedded) samples of normal prostate were subjected to exome sequencing.
Next, the effect of all the platinum II) compounds on the viability of normal or cancer cells and their putative mechanisms of action have been investigated.
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