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In the isomorphism algorithm each screened database compound needs to be materialized as a CDK molecule to be able to compare it to the query structure.
Semiochemicals are often produced in infinitesimally small quantities, so their isolation requires large amounts of starting material, not only requiring significant effort in sample preparation, but also resulting in a complex mixture of compounds from which the bioactive compound needs to be purified and identified.
This compound needs to be converted further.
The reaction mechanisms involved in the formation of these compound needs to be further investigated.
Though the antitumor activities of these compounds had been previously reported, the mechanism(s) of antitumor activity of the individual compound needs to be investigated.
Secondly, the immature brain undergoes major developmental changes that will determine the long-term cognitive and motor outcome, meaning that the safety of every compound needs to be carefully tested in long-term follow-up studies.
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It should be noted that less than 3 micro moles in total of each compound needed to be handled by the manipulator on the arrayer platform.
As the next step towards animal experiments, the slight acid sensitivity of compound 3 (resulting in its decomposition to compound 2 with a half-life of ca. 7.30 min at gastric pH [ 7]), as well as solubility problems attributed to this compound needed to be solved; in order to fulfill these objectives, liposomal formulations were developed.
In addition to specific activity the stability of the purified MnP enzymes towards temperature, pH and inactivating compounds needs to be studied before candidates for recombinant production are selected.
The volume of the tested compound such as potentially toxic compounds needs to be reduced in order to reduce hazards to the manipulators; c.
Accordingly, the invariant portion of these compounds needs to be synthesized only once.
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CEO of Professional Science Editing for Scientists @ prosciediting.com