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Usually, the test compound is administered prior to the thrombus formation.
When this compound is administered to patients, the degradation of tegafur is competitively inhibited by uracil, a substrate of DPD, in a reversible manner.
When this artificial probe compound is administered to the organism, it becomes concentrated within the mitochondria, where it is converted to its alternative form MitoP by H2O2.
Hence, this reduced perfusion could induce an increase in hypoxic fraction within treated tumours that could potentially affect the tumour response to radiotherapy when an anti-angiogenic compound is administered before or during radiotherapy.
The E-screen test also revealed that estrogenic chemicals may act cumulatively; when mixed together they induce estrogenic responses at concentrations lower than those required when each compound is administered alone.
Best tissue distribution rates are expected when the active compound is administered in a formulation with homogeneously distributed particles of low size, which is the case for Orbenin Extra Dry Cow, where the low particle size is obtained by the bead milling process of the formulation (Dynomill process).
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3H-radiolabelled compound was administered i.v. or loaded to the perfusion medium, respectively.
Furthermore, when the compound was administered 1 h post-stroke, a similar effect was observed.
The reduced potency of CP-99,994 probably reflects the poor oral bioavailability of this compound, for when the compound was administered i.p., the MED dose of CP-99,994 decreased to 1 mg/kg (see Table 2).
Because they knew that humans would be taking rutin in pill form, they included studies in which the compound was administered orally and determined that it successfully retained its anti-thrombotic properties when it was metabolized following oral ingestion.
The compound was administered to 22 inpatients with schizophrenia in an open, dose‐ranging pilot study designed to assess antipsychotic effects as well as side effect profile.
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