Sentence examples for compound interaction with from inspiring English sources

They retained the parent compound interaction with the receptor; however the additional side groups made new interactions in the binding site.

Molecular modeling of the SH2 domains of Stat3 and Stat1 bound to compound revealed that compound interaction with the hydrophobic binding site was the basis for selectivity.

For both DOX and DMNQ biochemical analysis indicated a loss of activity in complex I (Figure 4) commensurate with a main compound interaction with this complex, and additionally a slight increase in Complex IV activity similar to that observed previously in DOX treated rats [40].

Moreover, Clemens Steegborn showed data indicating that modulation of SIRT1 by resveratrol is substrate-specific and that this effect might be due to compound interaction with both the enzyme and its substrate.

Compound descriptor array based methods use machine learning approaches to relate compound interactions with arrays of observations regarding a compound.

Compounds described here were compared with previously published pyrimidinebenzenesulfonamides.1 Systematic structure activity analysis of 40 compound interactions with six isoforms yields clues for the design of compounds with greater affinities and selectivities towards target CA isoforms.

There are three general modes of binding that characterize the compound interactions with double-stranded DNA: intercalation, groove binding and covalent binding [ 92- 94].

Since evidence for the direct interaction of KAR1 with KAI2 is equivocal, there remains the possibility that the karrikin compounds found in smoke require uptake and conversion by the seed into an active compound before interaction with KAI2.

Trans-ISRIB proved 100-fold more potent (IC50 = 5 nM) than cis-ISRIB (IC50 = 600 nM), indicating that the compound's interaction with its cellular target is stereospecific.

Studies are now aimed at performing a more detailed structure activity relationship to identify the mode of the compound's interaction with ERK, improve potency, and determine whether other substrate proteins are affected.

In addition, a more pronounced enhancement of the emission intensity was observed from these d-A-D compounds upon interaction with the fibrils.