If a compound interacts with too many molecules in addition to the specific target, it will often cause problems independently of its work in curing the disease.
Second, from the interactome compounds known to interact with the k-th protein (k = 1, 2,…, p), we select an interactome compound with the highest similarity to the query constituent compound and use the corresponding similarity score as a prediction score to assess the possibility that the query compound interacts with the k-th protein.
In conclusion, this system has the capability to incorporate the cholesterol‐based compound, interact with native LDL, and assist the delivery of this compound into cancer cells in vitro.
5. What liver-expressed proteins can a given compound interact with? 6.
This new compound interacts with a cellulose surface resulting in chemisorption and physisorption effects, with a minimum distance of 4.8665 Å between each other in physisorption case (Fig. 14b) (see "Adsorption" section).
Thus far, effective research regarding natural compound is attaining much, but research has scarcely been able to demonstrate a feasible effect because compound interacts with certain proteins.
Inhibition of uptake indicates that a compound interacts with the transporter.
More detailed knowledge of how a single compound interacts with three distinct chemokine receptors should facilitate the discovery of similar broad spectrum antagonists with therapeutic potential.
A single experiment was defined as "positive", i.e. the compound interacts with the protein, if the measured value was above the threshold.
The X-ray crystal structure of this compound with Cdk2 has been reported, and has revealed the mechanisms by which this compound interacts with the Cdk2 ATP binding site (Misra et al, 2004).
