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Thus, the AGS compound increased the survival rate by twofold (p < 0.01) as compared to vehicle.
These results suggest that the AGS compound increased the survival of ALS mice in a dose- and time-dependent manner.
Pre-treatment of mice with the AGS-499 compound increased the survival rate of the NMDA-injected mice from 64 to 85% (p < 0.05) (Fig 5B).
We confirmed that doxorubicin stimulated ceramide synthesis by showing that treatment with the compound increased the amount of [C]palmitate incorporated into ceramide in Huh7 cells.
Treatment with either compound increased the number of gems in 3813 fibroblasts by nearly twofold at concentrations between 370 nM and 3.3 µM.
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Blocking AdipoR1 using AdipoR1 blocker compound increases the mRNA levels of p21, p53, and c-Myc in the NSCs compared with the Acrp30 (30 μg/ml) treatment.
The syntheses of ceramic phase and some intermetallic compounds increased the hardness of the coating.
Both carbon compounds increased the abundance of obligate microbial-feeding nematodes, indicating enhanced microbial production.
It was found that aromatic and hydrogen donor compounds increased the onset ratio by a slight to moderate degree, heteroatom compounds increased the onset ratio by a moderate degree, whereas surfactants increased the onset ratio by the highest degree.
In pin-on-disc wear tests against Al2O3-balls, induction surface hardening of the most coating/substrate compounds increased the wear resistance significantly.
All the compounds increased the susceptibility of mitochondria to MPT, but, OSI-3701, not affecting the bioenergetic parameters, was the most potent.
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