Sentence examples for compound in the development from inspiring English sources

15k is a potentially valuable lead compound in the development of safe and efficacious GPR40-targeted drugs to treat type 2 diabetes mellitus.

FAS has little effect on normal cells because they take up dietary lipids but, in tumor cells, FAS is upregulated and contributes to angiogenesis; thus THL is currently a lead compound in the development of anticancer drugs [28], [34].

In conclusion, nordihydroguaiaretic acid could constitute a lead compound in the development of novel therapeutic agents for various types of cancer.

The results suggested that the structural modifications of isocorydine at C-8 could significantly improve the biological activity of this alkaloid, indicating its suitability as a lead compound in the development of an effective anticancer agent 16, 17.

Given its ability to selectively kill cancer cells in vivo and in vitro without systemic toxicity, AUL12 could constitute a leading compound in the development of chemotherapeutics that target the unique neoplastic alterations of the cell redox equilibrium.

In fact, the glycoprotein has been quite often selected as a model compound in the development of new strategies for the structural analysis of N-glycosylation patterns, making use of chemically or enzymatically released carbohydrate chains from denatured material.

Chemical database screening yielded several potent inhibitor candidates such as alkylamine derivatives (compound no. 5, IC50 = 0.1 μM) and 1-benzothiophene-3-carbaldehyde that can be used as lead compounds in the development of drugs for smoking reduction therapy.

The significant and comparable in vivo anti-tumour activity of the diblock HMW conjugate and an equimolar mixture of the conjugates differing in the DOX attachment method along with the development of cancer resistance during treatment with these conjugates demonstrated the high potential of these compounds in the development of new nanomedicines suitable for the treatment of solid tumours.

Taken together, these findings suggest novel routes towards the design of activators or inhibitors that modulate the production of H2S; these modulators may also serve as lead compounds in the development of drugs or mechanistic probes in the study of various H2S-related diseases.

This knowledge allows an earlier rejection of those chemicals that may fail the testing phase and reduces the cost of manufacturing chemical compounds in the development stage.

The transgenic mice used in this study may be useful for screening compounds in the development of new mechanistically-novel anti-depressant drugs.