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This study was designed to determine the effect of diphenyl diselenide (PhSe 2, a synthetic organoselenium compound, in comparison with ebselen, on peroxynitrite-mediated endothelial damage.
To explore whether resistance to JMN3-003 could be induced experimentally, we attempted stepwise viral adaptation to growth in the presence of the compound in comparison with the pathogen-specific MeV RdRp inhibitor AS-136A [36].
Nevertheless, future pharmacokinetic studies of this compound, in comparison with its analogues, will increase the understanding of its mode of action and contribute to the better design of preclinical and clinical trials.
Having determined the key characteristics of ETP-45658, we evaluated the inhibitory activity of this compound (in comparison to PI-103) against each member of the PI3K family, including PI3K class 1 isoforms in addition to distinct p110 mutants.
Relative potency values express the potency of a specific compound in comparison to 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD), the most potent dioxinlike compound, with a relative potency value of 1.
As a chemically unique compound in comparison with other agents under study for AD, namely tacrine, galanthamine, donepezil, and rivastigmine, HupA is a reversible, potent, and selective acetylcholinesterase (AChE) inhibitor, and has been found to improve cognitive deficits in a broad range of animal models (Wang et al 2006a).
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The reduction in process time due to RF heating helped in retention of many volatile compounds in comparison with conventional hot water heating.
The current study aims to screen for the biofilm forming isolates from infected eyes and CL-cases and to evaluate the anti-biofilm activity of some natural compounds in comparison to three CL-care solutions.
Nevertheless, the present work provides more information about these features, since five different antioxidant methods were used to analyze the antioxidant capacity of these compounds in comparison with standards i.e., Ascorbic acid, gallic acid, BHT and rutin.
Furthermore, five representative compounds were subjected to three more enzyme assays (on carbonic anhydrase II, papain and the lipase from Candida antarctica) to gain information about the selectivity of the compounds in comparison to other enzymes.
Computational analysis of the binding mode of these compounds in comparison to their target protein has been performed only on crystallographic static structures, therefore missing the evolution of the complex during time.
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