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The new method consumes just about 35 min for each analysis, displays resistance to pre-existed NHS, is universally applicable to common active esters as long as they are stable in DMF, and requires just one easily-accessible reference compound for different NHS esters.
On testing this compound for different enamine- or iminium-catalysed reactions we found that it only held promise for iminium activation.
Apart from the predisposing factors, we might suppose that the level of TdP risk conferred by a particular drug will depend upon the affinity of the drug compound for different ion channels, and its concentration.
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Radioligand-binding experiments were performed in cells expressing A2AR-D2R and A1R-A2AR heteromers to determine possible differences in the affinity of these compounds for different A2AR heteromers.
Radioligand-binding experiments were performed in CHO cells stably expressing A2AR, A2AR-D2R heterorers or A1R-A2AR hetoromers to determine possible differences in the affinity of these compounds for different A2AR heteromers.
Approaches which can predict the inhibition ability of compounds for different NR target should be particularly helpful for drug development.
Allyl 1-naphthyl ethers are useful compounds for different purposes, but reported methods to synthesize them require long reaction times.
Sunbelt boasts a unique technology that allows the same paints to coat every type of car, instead of requiring separate compounds for different makes.
Cells were then incubated with different concentrations of compounds for different times, and subsequently stimulated with 10 ng/mL TNF-α for 4 h.
Using a specific encoding, ranking methods can be applied to infer a model for a certain activity profile of compounds for different biological targets.
FKuR launched a biopolymer business in the year 2000 and has a capacity of 2,800 metric ton/year of various cellulosic compounds for different applications (Doug 2010).
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