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The results indicated that compound 8b is an excellent multifunctional promising compound for development of novel drugs for Alzheimer's disease (AD).
Our study suggested that single agents inhibiting Topo and PARP concurrently might be an alternative for cancer therapy and 11l represented a potential lead compound for development of antitumor agents.
Q7R could be considered as a lead compound for development of anti-PEDV drugs to may be used to during the early stage of PEDV replication and the structure-activity data of Q7R may usefully guideline to design other related antiviral agents.
TLM is also orally available and non-toxic in the mouse model, which makes it an attractive compound for development.
LK-A is therefore a potential lead compound for development of antitumor drugs targeting HCC.
IGR seems to be a suitable natural compound for development of new anti-inflammatory ingredient.
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The identification of active components in natural products provides lead compounds for development into a drug.
The biological activities of the compounds are in Tables 1, 2. The most active antimycobacterial compounds 15 17 had selectivity indices 11 69 (Table 1) representing an acceptable margin for carrying forward the compounds for development as TB drugs.
This level of activity warrants further investigation of the compounds for development as anticancer and antimalarial agents.
Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.
These studies demonstrate that CADD can be used to identify lead compounds for development of novel non-ATP-dependent inhibitors selective for active ERK and its interactions with substrates involved in cancer cell proliferation.
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