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In contrast, this compound fails to inhibit cell growth or induce cell apoptosis [ 137].
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A second Targacept compound failed in tests against ADHD.
Of note, this compound failed to modulate BCR-ABL and Crkl phosphorylation at the same time, indicating that the acadesine anti-leukemic effect is independent on BCR-ABL.
The compound failed to show efficacy, and development was halted in 2008 [ 29].
However, this compound failed to extend survival time in an acute mouse model of African trypanosomiasis.
Phase III relates to patients for whom the first biological compound failed (statement No 9).
The doses used in the clinical program were limited by ARIA, and finally the compound failed to show efficacy.
Although ZM336372 effectively inhibited purified BRAF and CRAF in vitro, the compound failed to suppress MEK phosphorylation in cells.
When the ultimate DNA-damaging metabolite BPDE was directly applied to HaCaT cells, this compound failed to promote CD95L-induced apoptosis.
As expected from the DSF data, the GW806742X compound failed to inhibit any of the kinases and was not further considered.
However, when tested in the presence of 4.5 nM Fl-E2, the compound failed to displace the fluorescently labelled ligand, even at concentrations as high as 150 μM (binding affinity approximately 1/30,000th that of E2).
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CEO of Professional Science Editing for Scientists @ prosciediting.com