Classically, morphological assessment of the embryos is applied to evaluate the effects of compound exposure.
There was no direct correlation between compound exposure and in vivo activity.
After compound exposure, cell viability was assessed by the commonly used MTT assay.
Compounds with a CIx ≥ 0.80 (i.e. 20% or less difference in cell viability between compound and BA co-exposure and compound exposure alone) were considered to have a low cholestatic risk, whereas compounds with a CIx ≤ 0.80 were considered to have cholestatic risk.
The impact of EWRS activities on organohalogen compound exposure of individuals working at and living in the surroundings of the Agbogbloshie EWRS, and the surprisingly high PCB exposure of people living in Accra not involved in e-waste activities require further investigation.
The device is designed for screening the combinatorial effects of multiple compound exposure on cultured cells, and a 1 cm × 1 cm proof-of-concept chip having a three-input combinatorial mixer and eight individually isolated micro culture-chambers has been fabricated.
Computational toxicology aims at predicting in silico the health and environmental risks associated to compound exposure or intake.
Hepatic ethoxyresorufin-O-deethylase activity, a biomarker of dioxin-like compound exposure, was induced by 12-fold in the 4600 pg/g treatment relative to controls.
To determine if reducing DCU particle size would improve compound exposure, a 30 mg/kg oral suspension and two oral nanosuspension doses (10 and 30 mg/kg) were administered to SD rats.
The data were presented as mean ± S.D. We found that synthesized intercalation compound exposure effectively reduced cell viability of human dermal fibroblasts at concentration 25 μg/mL and above.
Compound exposure experiments were performed on wild-type larvae from 2 days post-fertilization (d.p.f).
