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Here we report the crystal structure of the BIR3 domain from XIAP in complex with Smac037, a compound designed according to structural principles emerging from our previously analyzed XIAP BIR3/Smac-mimetic complexes.
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The compounds were designed according to a dual-tails approach to modulate the interactions of the ligands portions at the outer rim of both hydrophobic and hydrophilic active site halves of human isoforms of carbonic anhydrase (CA, EC 4.2.1.1).
Systems are designed according to language pairs.
The research is designed according to survey.
Primers were designed according to Gewaltig [ 23].
The VPs were designed according to published design criteria [ 28].
That's by design, according to Counsell.
To overcome the disadvantages of ASA and eugenol, aspirin eugenol ester (AEE) as a novel medicinal compound was designed and synthesized according to the prodrug principles of structure recombination [ 15].
Compound 2 shared the same skeleton as compound 1 according to the NMR data (Table 1).
Sample size ranged from 300 to 1368 compounds according to the design and expected vaccination coverage (from 45%to90%0%).
Target compounds align according to their order of elution along the second dimension rather than absolute coordinates by design, thus rendering their location with respect to relative order of elution instead of specific retention times.
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CEO of Professional Science Editing for Scientists @ prosciediting.com