Sentence examples for compound coverage from inspiring English sources

With increasing compound coverage, the fraction of scaffolds involved in both scaffold hopping and activity cliff formation significantly increased to more than 50%.

Ultraviolet photoelectron spectroscopy (UPS) measurement on a range of artificially created ITO-Au heterogeneous surfaces demonstrates that contributions to the secondary electron cut-off are not proportional to the compound coverage on the surface and that the lower workfunction material dominates the secondary electron cut-off.

No doubt the use of better instruments (i.e. faster scanning quadrupoles or TOF instruments with greater sensitivity), multiple extraction steps or the use of different derivatization steps could have improved compound coverage.

Even though NMR provides advantages for quantitative and structural metabolomics [26], LC/MS- and GC/MS-based metabolite profiling have become the methods of choice for a general overview of cellular metabolism due to their high throughput, compound coverage, and sensitivity [27].

Furthermore, the pharmacodynamics analysis suggests that 5-hour compound coverage was sufficient to ameliorate the disease in this model.

In particular, 6 12 h compound coverage (Additional file 1) was sufficient to ameliorate the disease in this model and allow enough time for most basic physiological processes to recover homeostasis.

Highest enrichment was considered as the highest averaged active compounds coverage over the entire enrichment curve and across all six compounds (Fig. 3).

For compound 2, density coverage reached values two times larger than the maximum value for compounds of the polyproline series (for details see Supporting Information, Figure S4c).

However, these screens were conducted with a limited number of compounds (100 38 000) or cell extract fractions, with several screens using the same library of 16 320 compounds, thus limiting compound diversity, chemical coverage, and opportunities for novel discoveries.

Although the TAS results showed a relatively robust behavior (supplementary material Fig. S10), future improvements in both the compound and target coverage of the quantitative bioactivity mappings should lead to further improvements in the performance of computational target deconvolution methods.

As a result, the country has a low routine immunization coverage compounding into one of the highest rates of unvaccinated children in the world.