Sentence examples for compound binding to from inspiring English sources

14 16 The microfluidics system of the biosensor allows the injection of the compound over an immobilised protein and the optical detector measures the direct binding between the two entities based on the difference in refractive index near the surface that occurs as the compound binds, thus allowing a real-time and label-free measurement of compound binding to the target.

More importantly, solution NMR analysis of compound binding to eParE provides better understanding of the molecular interactions between the inhibitor and eParE.

From the structure and dynamics of the protein ligand complex and efficient, detailed free energy calculations an atomic view of the ligand protein interactions is obtained which is used to design a new compound binding to the receptor.

However, sulfonamide compound binding to CA IX is linked to several reactions, the deprotonation of the sulfonamide amino group and the protonation of the CA active site Zn II -bound hydroxide.

Further studies are underway to explore aspects of bivalent ligand and control compound binding to the ERs and their effects on ER dimer formation; these results will be reported in a subsequent publication.

During early-phase drug development, typically, such in vitro studies are conducted under closed-system conditions as saturation and competition experiments, which provide quantitative parameters for the extent of compound binding to a target region (e.g. receptor) according to the law of mass action [1].

The method exploits affinity data for a series of organic chemical compounds binding to wild-type and artificially mutated receptors.

The ability to collect kinetic data on compounds binding to therapeutic targets yields new information for lead optimization.

Data mining using resources like Metrabase can be employed to understand, for example, transporter function or the promiscuous nature of compounds binding to transporters competitively or non-competitively.

Data mining using resources like IDAAPM can be employed to understand, for example, target function or the promiscuous nature of compounds binding to specific types of proteins.

For computational methods it is more difficult to study selectivity than activity because selectivity analysis requires the evaluation of compounds binding to multiple targets [2].