In 1967, the biochemists Arthur Bell and Peter Nunn reported that they had isolated the toxic compound beta-methylamino-L-alanin, or BMAA in cycad seeds.
The effect on MTT conversion to formazan (MTT measures mitochondrial enzymatic activity [20], [34]) by all three compounds, BetA, BE and cholesterol, suggests a common target in the mitochondria.
A number of pharmaceutical classes were monitored, including estrogenic compounds, beta-blockers, antibacterial agents, antidepressants, NSAIDs, antibiotics, and lipid regulators.
In all, 92% of children who had clinically manifested beta-thalassemia had the beta-thalassemia major phenotype and more than 85% of pediatric patients with beta-thalassemia major had compound heterozygous beta- thalassemia and HbE, which is highly prevalent in Thailand.
21 A total of 88 beta-thalassemia alleles from eight homozygous or compound heterozygous beta-thalassemia patients, 57 beta-thalassemia/HbE patients, and 15 heterozygous beta-thalassemia individuals were included in our study.
However, our molecular dynamics studies revealed that in the compound 1: beta lactamase complex, the flexibility of Ω-loop was restricted.
We reproduced effects of STZ, an alkylating compound causing beta pancreatic cell death, described by others [ 32- 34].
Sixty-five patients had clinically manifested beta-thalassemia including 57 with beta-thalassemia/HbE and eight with homozygous or compound heterozygous beta-thalassemia.
Alternatively, all patients with homozygous or compound heterozygous beta-thalassemia and 91.2% (52/57) of beta-thalassemia/HbE patients in this study presented with severe transfusion dependent beta-thalassemia major.
5, 6, 8, 10 As in our study, 85% of beta-thalassemia major patients and 100% of TI patients had compound heterozygous beta-thalassemia and HbE.
In the 60 beta-thalassemia major patients, 86.7% (52/60) of patients had beta-thalassemia/HbE whereas only 13.3% (8/60) of patients had homozygous or compound heterozygous beta-thalassemia.
