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This new compound approach is able to extract and characterize powder features, such as particle size(s), shape(s), smoothness, coarseness, graininess, mixing homogeneity, as well as to classify and discriminate between different powders and even predict bulk behavioral properties.
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A model compound approach was employed to demonstrate successful amine attachment to the polymer, together with its compatibility and suitability within the polymer system.
The compound distribution approach is preferred over the conventional method since it does not rely solely upon the maximum value but rather utilizes directly more of the available information.
In this paper, an effective and efficient compound-identification approach is proposed based on the frequency features of mass spectra.
Because HSV1-TK converts acycloguanosine prodrugs to toxic compounds, this approach is used in cancer gene therapy protocols as a suicide gene approach [ 26].
Similarly, if there is no consistent pattern of variation in exposure levels throughout the week, as seemed to be the case in our population for most compounds, our approach is unlikely to correct for daily variations in exposure and thus to make biomarker levels more representative of the weekly exposure average.
Despite this, we show that the compound fitness function approach is a reliable solution to global optimisation of the laser operating state.
In case a database does not contain the sample compound an obvious approach is to search for similar spectra, assuming that spectral similarity is based on structural similarity of the compounds.
Using this threshold, the sensitivity (ability to detect true-positive compounds) of this approach is 73%, whereas the specificity (ability to detect true-negative compounds) of this approach is 86%.
For novel compounds such an approach is not feasible because they do not necessarily inhibit ovulation and no other surrogate endpoint for pregnancy is available.
In this study, we used HIV protease inhibitors as model compounds, but the approach is also applicable to other drugs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com