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Extensive compound analyses can also be performed through web-application for prioritizing drug-like compounds.
Yap, who joined the centre in 1996, provides expert analytical services in areas such as drug analysis, trace evidence, arson, oil spills, miscellaneous organic compound analyses, obliterated stamped marks, shoeprints, damages, physical comparisons, and firearms.
To resolve this apparent paradox, we compared our compound analyses with those reported by Wilson et al. We found that spectroscopic data matched well in some cases but detected discrepancies for those compounds where the pharmacological data is at variance (i.e. 10 and 18, corresponding to compounds 27 and 28, respectively, in Wilson et al. ).
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In the remaining fractions, the quantities of particular compounds were different and depended on the fraction and the compound analysed.
The column used, conditions of elution, and purity of sample are as indicated for each compound analysed.
In control reactions and blanks, the same amount of solvent used for its stock solution or compound analysed, respectively, was included.
Taken together, these results support the robustness of the 10-compound analyses.
While LC combined with tandem mass spectrometry (LC MS MS) has excellent sensitivity and selectivity for target analytes in doping analysis [ 3– 6], true multi-compound analyses requires a sensitive full-scan MS technique, for example time-of-flight mass spectrometry (TOFMS) or Orbitrap mass spectrometry [ 7– 9].
The diXa homepage (see Supplementary Fig. S1) provides 'search' and 'browse' sections allowing querying and browsing by studies, samples, compounds, analyses or diseases (see Supplementary Figs.S2 S11).S2 S11
We stress that this compounded analyses of the effects of TFAs from PHVO on plasma lipids is based on 23 studies to date, whereas rTFAs have been investigated in only 5 studies so far (2), excluding the current study.
In this review, to improve the body of information in this field, we report structure activity-relationships (SARs) of benzomorphan-based compounds analysing data literature of last 25 years.
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