Thus, this suggests that some of the target compounds activated by NQO1 are novel prodrug candidates potential for selective anticancer therapy.
Thiols add across to the multiple bond of unsaturated compounds, either under catalysis by light or acid or, in the case of unsaturated compounds activated by adjacent carbonyl groups, under catalysis by base.
This "communication" between hepatocytes and LSECs is very specific for vinyl chloride and not observed for many other genotoxic compounds activated by hepatocytes (Cohen et al. 2009).
Such compounds are activated by the enzyme to the corresponding radicals.
Photodynamic therapy, in which systemically administered photosensitive compounds are activated by an external light source, can be considered a related strategy to drug delivery and is under investigation for the treatment of superficial breast tumors.
After the synthesis of gentisate, this compound will be activated by the addition of a CoA group.
Some drugs contain compounds that, when activated by the sun's ultraviolet A (UVA) radiation, can damage cell membranes and, in some instances, DNA.
These compounds are generally activated by reduction in hypoxic conditions and work in a similar way to oxygen by causing DNA double strand breaks in the presence of irradiation as a result of the fixation of free radical damage (Katz et al. [2009]).
During phase I, compounds can be activated by oxidation reactions resulting in the formation of highly reactive, electrophilic intermediates.
Thus, depending on the specificity of the enzymes involved, N-substituted aromatic compounds may be activated by N,O-acyltransfer during both the acetylation and deacylation process.
