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Unfortunately, there was barely microorganism possessing the compound ability of lignocellulose decomposition and solvents production natively.
In separate experiments, CellEvent Caspase 3/7 reagent (Life Technologies) was used to evaluate compound ability to trigger apoptosis signaling.
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Interference with MT polymerization was validated by the compounds' ability to inhibit MT assembly at the biochemical and cellular level.
Zadina's team tested the compounds' ability to dull pain by injecting them into the brains and spinal cords of mice, then placing each mouse's tail under a hot light.
The controversy: A 2005 study found that constant application of antiperspirants containing aluminum chloride or aluminum chlorhydrate could be related to an increase in breast cancer cells because of the compounds' ability to mimic estrogen in the body.
We speculate that these observations may result from the compounds' ability to enter the cell.
In addition, a shortcoming of these assays is that they do not assess for a compounds' ability to modulate chemosensitivity.
Therefore, to exclude false positives we validated the compounds' ability to specifically suppress 3Dpol activity with fluorescently labeled primer-extension assays.
The extent and relative persistence of total DNA binding correlated with the compounds' ability to induce bladder tumors in dogs.
Both XE mixtures with E2 failed to stimulate cell proliferation, but instead suppressed cell numbers far below those seen with vehicle, again showing these compounds' ability to disrupt a response to a physiologic estrogen.
A methoxy group was mandatory at position 6, whereas either H or methoxy was allowed at vicinal position 5. Interestingly, extended SAR studies of xanthones demonstrated that the compounds' ability to trigger MRP1-mediated GSH efflux is not directly linked to MDR-selective toxicity, because several compounds induced a strong GSH efflux but were not selectively cytotoxic.
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