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The compositions of the model structures are kept as close to 40 at% Pt as possible, so that details in the simulated STEM images and EDX maps can be compared with each other without needing to consider differences in their average composition.
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The exact knowledge of the material composition of the model elements is needed.
Competent cross-membrane transport and membrane disruption were observed with a strong dependence on dendrimer size (generation), chemical structure, and composition of the model membranes [26, 53].
A key issue in the design of extractables studies is the composition of the model solvent, in particular its pH and polarity.
The solid form composition of the model APIs, theophylline and carbamazepine, was of specific interest, and its possible impact on the in vitro drug release behavior.
Knowledge of w, initial values, and the time trajectory of the τ j thus allow the composition of the model to be analytically projected as far into the future as the τ jtsequence extends.
In this study, a new approach, based on design of experiments (DoE), has been applied to determine the composition of the model solvent for extractable profiling of single-use bags (SUBs).
The composition of the model population also had a significant impact on the results.
The fluidic SLB format allowed us to easily tune the composition of the model membrane surface by quantitatively mixing functional lipids with matrix lipids for SLB formation.
All were entered into the model, and a stepwise selection process combined with finding a parsimonious minimum of the Akaike and Schwarz model information criteria [ 19] resulted in the final composition of the model.
In general it was observed that the number of significantly altered genes increased with increasing complexity of the liver model (with regard to duration of the treatment and cellular composition of the model).
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