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The same lipid composition was administered to cynomolgus monkeys but with an encapsulated siRNA targeting hepatic transthyretin (TTR), a gene of therapeutic interest in the treatment of familial amyloidotic polyneuropathy.[ 16] Animals received a 15 min intravenous infusion at siRNA doses of 0.03, 0.1, or 0.3 mg kg−1 and from the dose response curve an ED50 less than 0.03 mg kg−1 was obtained.
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Finally, it should be noted that ethnic and family composition was more homogenous when the questionnaire was administered than currently in Spain.
Buprenorphine was administered intramuscularly.
Close-ended questionnaire (N = 247) on the phenomena was administered in each building.
[27] was administered.
No premedication was administered.
Neuropsychological testing was administered.
Sumatriptan was administered subcutaneously (s.c).
No adjuvant chemotherapy was administered.
I was administering drugs".
Compositions are summarised in appendix 1. Formulas were administered as previously described, starting 25.3±5.6 versus 23.4±5.4 h after PICU-admission in the PE-group and S-group, respectively.
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