Apart from TRAIL receptor composition, [ 17, 18] there are a number of other possible reasons why some cancer cells exhibit TRAIL resistance.
Novel quantitative Real Time RT-PCR and flow cytometry analysis were performed to disclose TRAIL receptor composition in breast cancer cells.
While Real Time PCR assay is useful in assessing the level of gene expression on mRNA levels, obviously this assay does not necessarily reflect TRAIL receptor composition on cell surface.
Resistance to TRAIL-induced apoptosis can be caused by the expression levels and composition of proapoptotic and decoy TRAIL receptors as well as by intracellular mechanisms.
Changes in the composition of this complex during TRAIL-mediated apoptosis were detected by tandem LC-MS/MS showing there is an increase in the levels of hnRNPC1/C2 and hnRNPA2/B1 although no significant differences in hnRNPA2/B1 were detected by western blotting.
Importantly, we show that uPA depletion alters the DISC composition by reducing the preligand and TRAIL-induced DcR2 DR5 interaction.
We analyzed how road distance and skid trail presence affect stand plant communities by examining species composition, distribution of biological and ecological traits, individual species responses and environmental plant indicator values.
Different growth habits (compact, trailing and intermediate) did not possess distinct genetic composition.
The hotel and offices can be read as a single, extraordinarily violent architectural composition, a wildly thrashing monster, its tail flapping up and down, trailing behind two giant elephant's legs.
For the artist James Welling and the filmmaker Jane Weinstock, Kameon turned a steeply sloped front yard into a richly layered composition of acacia trees, juniper, aloe plants, purple flowering salvia and trailing rosemary, among other things.
