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Table 2 presents the body composition outcomes.
All 17 cohort studies reported body weight or body composition outcomes.
There were, however, no corresponding between-group differences in body composition outcomes at 12 months.
Cord DNA was selected for analysis from participants with subsequent neuro-cognitive and body composition outcomes.
No significant changes were found for most of the body composition outcomes.
A majority of the studies report body weight or body composition outcomes with duration greater than 1 month (Fig. 3).
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This showed that 90.8% (215419/237,152) of the regressions for the body composition outcome possessed significant heteroskedasticity.
New P values were therefore calculated in a heteroskedasticity-consistent (i.e. robust) manner for the body composition outcome and the distribution of these P values is shown in Figure 5.
As we observed a distribution of P values for these 4% datasets similar to Figure 1 for the neuro-cognitive outcome and similar to Figure 3 for the body composition outcome, we conclude that correlation between probes located in the same promoter region is unlikely to affect the shape of the P value distribution.
When the associations between the probe log ratio values and a continuous body composition outcome were assessed using linear regression, the distribution of P values shown in Figure 3 was obtained; fewer P values ≤ 0.05 were obtained than would be expected by chance.
It was therefore decided to test the residuals from all 237,152 regressions with the body composition outcome for heteroskedasticity using the Cook-Weisberg test, a standard statistical test [ 6] implemented in a commercial statistical software package [ 7] (Stata version 11.1, StataCorp, Texas, USA).
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